More than 140 scientific studies suggest that melatonin is a useful agent in treating SARS-CoV-2, according to research published in Cellular and Molecular Life Sciences.1 Despite this and its known antiviral and anti-inflammatory effects, melatonin has received little attention a countermeasure for COVID-19.
After reviewing the published literature on melatonin and SARS-CoV-2/COVID-19 in November 2021, the research team found that melatonin has been most widely studied for its ability to suppress inflammation and the cytokine storm associated with COVID-19.2 use of melatonin as a treatment for people infected with SARS-CoV-2 was another common theme.
Taken together, the data provide the rationale that melatonin could be used both as a prophylactic agent against COVID-19 and as a treatment tool. When melatonin was given to people with COVID-19, either alone or in combination with other treatments, the severity of infection was reduced, mortality rates were reduced, and hospital stays were shortened.
“Melatonin’s ability to halt SARS-CoV-2 infection may reduce healthcare fatigue by limiting the need for hospitalization,” the researchers noted, adding that it is also safe – “Melatonin has a high Safety profile over a wide dose range and is not significant toxicity.”3
One reason melatonin works as an anti-COVID-19 agent is because of its role against sepsis (blood poisoning). The researchers explained:4
“While SARS-CoV-2 infections are generally thought of as a pulmonary problem, the consequences of this infection go beyond the respiratory system. Ultimately, this disease becomes systemic with the development of severe sepsis or septic shock leading to multiple organ failure, which is the condition that often leads to the death of SARS-CoV-2 infected patients.”
Sepsis is a life-threatening condition triggered by a systemic infection that causes your body to overreact and trigger an excessive and extremely damaging immune response. Melatonin has prevented the death of newborns with severe bacterial sepsis5 and also appears to reverse symptoms of septic shock by:6