February 8, 2023

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The bradykinin hypothesis explains the complexity of COVID-19

Genetic analyzes using the Oak Ridge National Lab’s supercomputer called Summit have revealed an interesting new hypothesis that helps explain the course of COVID-19. A September 1, 2020 Medium article1 by Thomas Smith reviewed the results of the so-called bradykinin hypothesis.

As Smith reported, the computer processed data on more than 40,000 genes obtained from 17,000 genetic samples.

“Summit is the second fastest computer in the world, but the process – which analyzed 2.5 billion genetic combinations – still took more than a week. When Summit was finished, the researchers analyzed the results. It was, in the words of Dr. Daniel Jacobson, Principal Investigator and Chief Scientist for Computational Systems Biology at Oak Ridge, a ‘eureka moment’.”

Bradykinin is a chemical that helps regulate your blood pressure and is controlled by your renin-angiotensin system (RAS). As explained in the Academic Press book on Vitamin D (which has a significant impact on RAS):2

“The renin-angiotensin system (RAS) is a central regulator of renal and cardiovascular functions. Overactivation of the RAS leads to renal and cardiovascular diseases such as hypertension and chronic kidney disease, the major risk factors for stroke, myocardial infarction, congestive heart failure, progressive atherosclerosis and renal failure.”